Synapsis spoilt

Regenerative medicine spoilt for choice

Only ten years ago, 'stem cells' was a buzz word for all kinds of anticipated miracle cures, following the first production of human embryonic stem (ES) cell lines from blastocysts (early stage embryos) in 1998. As embryonic stem cells are pluripotent, they can generate the specialised cells for any kind of organ or tissue that one may want to create or repair, given the right enticement. While...

Outcomes of p53 activation--spoilt for choice.

The p53 tumour suppressor protein can efficiently inhibit tumour development. This activity reflects its ability to induce a number of different responses, including cell cycle arrest and apoptosis. Recent studies have revealed some interesting insights into how the choice of response to p53 is regulated, highlighting a correlation between the activation of cell cycle arrest and survival with t...

Centromere Clustering: Where Synapsis Begins

Centromeres congregate into a large cluster called the chromocenter during Drosophila oogenesis. Two recent studies now define a function and a genetic basis for this remarkable structure.

Titration of spoilt beer samples by flow-injection analysis

Spoilt for Choice: Full First-Order Hierarchical Decompositions

Database design aims to find a database schema that permits the efficient processing of common types of queries and updates on future database instances. Full first-order decompositions constitute a large class of database constraints that can provide assistance to the database designer in identifying a suitable database schema. We establish a finite axiomatisation of full first-order decomposi...